SYNAPTIC FUNCTION AND DYSFUNCTION IN BRAIN DISEASES
Regional Meeting of the International Society for Neurochemistry
Coimbra, Portugal 1 - 4 June 2016

KEYNOTE SPEAKERS

Dr. Daniel Choquet is research director at the CNRS, France, and a member of the French Academy of Sciences. He is director of the Institute for Interdisciplinary Neuroscience and the Bordeaux Imaging Center core facility. He is also the director of the center of excellence BRAIN, Bordeaux Region Aquitaine Initiative for Neuroscience. His team combines neuroscience, physics and chemistry in order to unravel the dynamics of multimolecular complexes and their role in synaptic transmission.
Selected references:
Choquet, D. and Triller, A. (2013) The dynamic synapse. Neuron, 80, 691-703.
Constals, A., Penn, A. C., Compans, B., Toulme, E., Phillipat, A., Marais, S., Retailleau, N., Hafner, A. S., Coussen, F., Hosy, E. and Choquet, D. (2015) Glutamate-induced AMPA receptor desensitization increases their mobility and modulates short-term plasticity through unbinding from Stargazin. Neuron, 85, 787-803.
Hafner, A. S., Penn, A. C., Grillo-Bosch, D., Retailleau, N., Poujol, C., Philippat, A., Coussen, F., Sainlos, M., Opazo, P. and Choquet, D. (2015) Lengthening of the Stargazin Cytoplasmic Tail Increases Synaptic Transmission by Promoting Interaction to Deeper Domains of PSD-95. Neuron, 86, 475-489.
Dr. Rui Costa is a Principal Investigator in the Champalimaud Neuroscience Program at the Champalimaud Center for the Unknown, Lisbon, Portugal. His laboratory studies the neurobiology of action in health and disease. Rui Costa uses genetic, electrophysiological, optical, and behavioral approaches to investigate the mechanisms underlying the generation and learning of novel actions.
Selected references:
Gremel, C. M. and Costa, R. M. (2013) Orbitofrontal and striatal circuits dynamically encode the shift between goal-directed and habitual actions. Nat Commun, 4, 2264.
Jin, X., Tecuapetla, F. and Costa, R. M. (2014) Basal ganglia subcircuits distinctively encode the parsing and concatenation of action sequences. Nat Neurosci, 17, 423-430.
Tecuapetla, F., Matias, S., Dugue, G. P., Mainen, Z. F. and Costa, R. M. (2014) Balanced activity in basal ganglia projection pathways is critical for contraversive movements. Nat Commun, 5, 4315.

 
Dr. Guoping Feng is the Poitras Professor of Neuroscience in the Department of Brain and Cognitive Sciences at MIT, an investigator at the McGovern Institute, and a senior scientist in the Broad Institute Stanley Center for Psychiatric Research. His research focuses on the molecular mechanisms of the synapse to understand how disruptions in these components can lead to psychiatric disease.
Selected references:
Burguiere, E., Monteiro, P., Feng, G. and Graybiel, A. M. (2013) Optogenetic stimulation of lateral orbitofronto-striatal pathway suppresses compulsive behaviors. Science, 340, 1243-1246.
Chen, Q., Cichon, J., Wang, W., Qiu, L., Lee, S. J., Campbell, N. R., Destefino, N., Goard, M. J., Fu, Z., Yasuda, R., Looger, L. L., Arenkiel, B. R., Gan, W. B. and Feng, G. (2012) Imaging neural activity using Thy1-GCaMP transgenic mice. Neuron, 76, 297-308.
Peca, J., Feliciano, C., Ting, J. T., Wang, W., Wells, M. F., Venkatraman, T. N., Lascola, C. D., Fu, Z. and Feng, G. (2011) Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. Nature, 472, 437-442.

 
Dr. Casper Hoogenraad is Professor of Cell Biology at the Faculty of Science, Utrecht University, The Netherlands. The primary goal of his lab is to understand how intracellular protein trafficking underlies neuronal development and function. In particular, his work is focused on i) Cytoskeleton dynamics during neurodevelopment and synaptic plasticity, ii) Motor proteins and adaptors as regulators of synaptic transport, and iii) Psychiatric and neurologic disease disorders linked to intracellular transport.
Selected references:
Jaarsma, D., van den Berg, R., Wulf, P. S., van Erp, S., Keijzer, N., Schlager, M. A., de Graaff, E., De Zeeuw, C. I., Pasterkamp, R. J., Akhmanova, A. and Hoogenraad, C. C. (2014) A role for Bicaudal-D2 in radial cerebellar granule cell migration. Nat Commun, 5, 3411.
Schlager, M. A., Serra-Marques, A., Grigoriev, I., Gumy, L. F., Esteves da Silva, M., Wulf, P. S., Akhmanova, A. and Hoogenraad, C. C. (2014) Bicaudal d family adaptor proteins control the velocity of Dynein-based movements. Cell Rep, 8, 1248-1256.
van Spronsen, M., Mikhaylova, M., Lipka, J., Schlager, M. A., van den Heuvel, D. J., Kuijpers, M., Wulf, P. S., Keijzer, N., Demmers, J., Kapitein, L. C., Jaarsma, D., Gerritsen, H. C., Akhmanova, A. and Hoogenraad, C. C. (2013) TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites. Neuron, 77, 485-502.

 
Dr. Richard Huganir is a Professor of Neuroscience, Biological Chemistry and Pharmacology and Molecular Science at the Johns Hopkins University School of Medicine. He serves as the director of the Solomon H. Snyder Department of Neuroscience at the Johns Hopkins University School of Medicine, and as the Co-Director of the Brain Science Institute. Dr. Huganir and his team focus their efforts on researching the mechanisms that regulate synaptic transmission and synaptic plasticity. The general approach is to study molecular and cellular mechanisms that regulate neurotransmitter receptors and synapse function.
Selected references:
Araki, Y., Zeng, M., Zhang, M. and Huganir, R. L. (2015) Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP. Neuron, 85, 173-189.
Diering, G. H., Gustina, A. S. and Huganir, R. L. (2014) PKA-GluA1 coupling via AKAP5 controls AMPA receptor phosphorylation and cell-surface targeting during bidirectional homeostatic plasticity. Neuron, 84, 790-805.
Zhang, Y., Cudmore, R. H., Lin, D. T., Linden, D. J. and Huganir, R. L. (2015) Visualization of NMDA receptor-dependent AMPA receptor synaptic plasticity in vivo. Nat Neurosci, 18, 402-407.

 
Dr. Alcino Silva is Professor of Neurobiology, Psychiatry & Biobehavioral Sciences and Psychology at UCLA. He also heads the Center for Genetic Studies of Coritical Plasticity and directs the UCLA Integrative Center for Learning and Memory. His laboratory studies mechanisms of memory and memory disorders, from molecular mechanisms to circuits and behavior, in rodents and patients. He is also interested in studying the mechanisms and developing treatments for the cognitive deficits associated with Schizophrenia and other psychiatric conditions.
Selected references:
Czajkowski, R., Jayaprakash, B., Wiltgen, B., Rogerson, T., Guzman-Karlsson, M. C., Barth, A. L., Trachtenberg, J. T. and Silva, A. J. (2014) Encoding and storage of spatial information in the retrosplenial cortex. Proc Natl Acad Sci U S A, 111, 8661-8666.
Lee, Y. S., Ehninger, D., Zhou, M., Oh, J. Y., Kang, M., Kwak, C., Ryu, H. H., Butz, D., Araki, T., Cai, Y., Balaji, J., Sano, Y., Nam, C. I., Kim, H. K., Kaang, B. K., Burger, C., Neel, B. G. and Silva, A. J. (2014) Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome. Nat Neurosci, 17, 1736-1743.
Sano, Y., Shobe, J. L., Zhou, M., Huang, S., Shuman, T., Cai, D. J., Golshani, P., Kamata, M. and Silva, A. J. (2014) CREB regulates memory allocation in the insular cortex. Curr Biol, 24, 2833-2837.

 

INVITED SPEAKERS

Dr. Camilla Bellone is an Assistant Professor at the Department of Fundamental Neuroscience of the University of Lausanne (Switzerland). Camilla did her PhD in the laboratory of Prof. Christian Lüscher at the University of Geneva, and her post-doc in the laboratory of Prof. Roger Nicoll at the UCSF. She focuses on the role of the reward system in neurodevelopmental disorders and she is currently investigating which are the molecular determinants that control the postnatal maturation of excitatory transmission onto the dopamine neurons of the Ventral Tegmental Area.
Selected references:
Bellone, C., Mameli, M. and Luscher, C. (2011) In utero exposure to cocaine delays postnatal synaptic maturation of glutamatergic transmission in the VTA. Nat Neurosci, 14, 1439-1446.
Kehoe, L. A., Bellone, C., De Roo, M., Zandueta, A., Dey, P. N., Perez-Otano, I. and Muller, D. (2014) GluN3A promotes dendritic spine pruning and destabilization during postnatal development. J Neurosci, 34, 9213-9221.
Yuan, T., Mameli, M., EC, O. C., Dey, P. N., Verpelli, C., Sala, C., Perez-Otano, I., Luscher, C. and Bellone, C. (2013) Expression of cocaine-evoked synaptic plasticity by GluN3A-containing NMDA receptors. Neuron, 80, 1025-1038.

 
Dr. Tobias Boeckers is currently Professor and Head of the Institute of Anatomy and Cell Biology, Dean of Studies and Board member of the Medical Faculty at Ulm University. His research is mainly dedicated to the understanding of molecular alterations at the synapse underlying neuropsychiatric disorders.
Selected references:
Grabrucker, A. M., Knight, M. J., Proepper, C., Bockmann, J., Joubert, M., Rowan, M., Nienhaus, G. U., Garner, C. C., Bowie, J. U., Kreutz, M. R., Gundelfinger, E. D. and Boeckers, T. M. (2011) Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation. EMBO J, 30, 569-581.
Grabrucker, S., Jannetti, L., Eckert, M., Gaub, S., Chhabra, R., Pfaender, S., Mangus, K., Reddy, P. P., Rankovic, V., Schmeisser, M. J., Kreutz, M. R., Ehret, G., Boeckers, T. M. and Grabrucker, A. M. (2014) Zinc deficiency dysregulates the synaptic ProSAP/Shank scaffold and might contribute to autism spectrum disorders. Brain, 137, 137-152.
Schmeisser, M. J., Ey, E., Wegener, S., Bockmann, J., Stempel, A. V., Kuebler, A., Janssen, A. L., Udvardi, P. T., Shiban, E., Spilker, C., Balschun, D., Skryabin, B. V., Dieck, S., Smalla, K. H., Montag, D., Leblond, C. S., Faure, P., Torquet, N., Le Sourd, A. M., Toro, R., Grabrucker, A. M., Shoichet, S. A., Schmitz, D., Kreutz, M. R., Bourgeron, T., Gundelfinger, E. D. and Boeckers, T. M. (2012) Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2. Nature, 486, 256-260.

 
Dr. Clive Bramham is Professor at the Faculty of Medicine and Dentistry and head of the Neuroscience Research group, at the University of Bergen, Norway. His research aims to elucidate the molecular mechanisms, regulation, and functions of long-term synaptic plasticity in the adult brain. In particular, his work addresses the following topics: i) Mechanisms of long-term potentiation consolidation; ii) Dendritic protein synthesis and translational control; iii) Function and molecular regulation of activity-regulated cytoskeleton-associated protein (Arc), iv) Dysfunction of synaptic plasticity in brain disorders.
Selected references:
Myrum C, Baumann A, Bustad H, Flydal M, Mariaule V, Alvira S, Cuéllar J, Haavik J, Soulé J, Valpuesta J, Márquez JA, Martinez A, Bramham CR (2015) Arc is a flexible modular protein capable of reversible self-oligomerization. Biochem J 468:145–158.
Panja, D., Kenney, J.W., D'Andrea, L., Zalfa, F., Vedeler, A., Wibrand, K., Fukunaga, R., Bagni, C., Proud, C.G.,Bramham, C.R., 2014. Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK. Cell Rep., 9, 1430-45.
Soulé, J., Alme, M., Myrum, C., Schubert, M., Kanhema, T., Bramham, C.R. (2012) Balancing Arc synthesis, mRNA decay, and proteasomal degradation: maximal protein expression triggered by rapid eye movement sleep-like bursts of muscarinic cholinergic receptor stimulation. J. Biol. Chem., 287, 22354-66. 
Dr. Ana Luisa Carvalho leads the Synapse Biology Group at the CNC-Center for Neuroscience and Cell Biology, University of Coimbra, and is an Assistant Professor at the Faculty of Sciences and Technology, University of Coimbra. Her research interests focus on the molecular and cellular mechanisms of synaptic plasticity and on alterations in synaptic function relevant in neuropsychiatric disorders.
Selected references:
Ferreira, J. S., Schmidt, J., Rio, P., Aguas, R., Rooyakkers, A., Li, K. W., Smit, A. B., Craig, A. M. and Carvalho, A. L. (2015) GluN2B-Containing NMDA Receptors Regulate AMPA Receptor Traffic through Anchoring of the Synaptic Proteasome. J Neurosci, 35, 8462-8479.
Louros, S. R., Hooks, B. M., Litvina, L., Carvalho, A. L. and Chen, C. (2014) A role for stargazin in experience-dependent plasticity. Cell Rep, 7, 1614-1625.
Ribeiro, L. F., Catarino, T., Santos, S. D., Benoist, M., van Leeuwen, J. F., Esteban, J. A. and Carvalho, A. L. (2014) Ghrelin triggers the synaptic incorporation of AMPA receptors in the hippocampus. Proc Natl Acad Sci U S A, 111, E149-158.

 
Dr. Rodrigo Cunha is the Head of the Neuromodulation group at the Center for Neuroscience and Cell Biology and Associate Professor at the Faculty of Medicine, University of Coimbra. The primary focus of his group are purine receptors (adenosine and ATP receptors) and their synergies with other modulation systems such cannabinoid or nicotinic receptors. In particular, the group of Dr. Rodrigo Cunha grasps the roles of purine receptors in normal brain function and their neuroprotective role in in vitro and in vivo models of chronic brain diseases.
Selected references:
Kaster, M. P., Machado, N. J., Silva, H. B., Nunes, A., Ardais, A. P., Santana, M., Baqi, Y., Muller, C. E., Rodrigues, A. L., Porciuncula, L. O., Chen, J. F., Tome, A. R., Agostinho, P., Canas, P. M. and Cunha, R. A. (2015) Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress. Proc Natl Acad Sci U S A, 112, 7833-7838.
Li, P., Rial, D., Canas, P. M., Yoo, J. H., Li, W., Zhou, X., Wang, Y., van Westen, G. J., Payen, M. P., Augusto, E., Goncalves, N., Tome, A. R., Li, Z., Wu, Z., Hou, X., Zhou, Y., A, P. I., Boyden, E. S., Cunha, R. A., Qu, J. and Chen, J. F. (2015) Optogenetic activation of intracellular adenosine A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory. Mol Psychiatry.
Matos, M., Shen, H. Y., Augusto, E., Wang, Y., Wei, C. J., Wang, Y. T., Agostinho, P., Boison, D., Cunha, R. A. and Chen, J. F. (2015) Deletion of Adenosine A Receptors from Astrocytes Disrupts Glutamate Homeostasis Leading to Psychomotor and Cognitive Impairment: Relevance to Schizophrenia. Biol Psychiatry. doi: 10.1016/j.biopsych.2015.02.026.

 
Dr. Carlos Duarte is Vice-President of the Center for Neuroscience and Cell Biology, University of Coimbra, and Head of the Growth Factor Signaling and Brain Ischemia group. He is also Associate Professor at the Faculty of Science, University of Coimbra. His research focuses on i) the molecular mechanisms underlying synaptic plasticity, particularly on the role of local protein synthesis, and on ii) the alterations in synaptic function resulting form excitotoxic damage (e.g. in brain ischemia) which have an impact in neuronal demise.
Selected references:
Gomes, J. R., Costa, J. T., Melo, C. V., Felizzi, F., Monteiro, P., Pinto, M. J., Inacio, A. R., Wieloch, T., Almeida, R. D., Graos, M. and Duarte, C. B. (2012) Excitotoxicity downregulates TrkB.FL signaling and upregulates the neuroprotective truncated TrkB receptors in cultured hippocampal and striatal neurons. J Neurosci, 32, 4610-4622.
Mele, M., Ribeiro, L., Inacio, A. R., Wieloch, T. and Duarte, C. B. (2014) GABAA receptor dephosphorylation followed by internalization is coupled to neuronal death in in vitro ischemia. Neurobiol Dis, 65, 220-232.
Santos, A. R., Mele, M., Vaz, S. H., Kellermayer, B., Grimaldi, M., Colino-Oliveira, M., Rombo, D. M., Comprido, D., Sebastiao, A. M. and Duarte, C. B. (2015) Differential role of the proteasome in the early and late phases of BDNF-induced facilitation of LTP. J Neurosci, 35, 3319-3329.

 
Dr. José A. Esteban is a Professor at the Centro de Biología Molecular “Severo Ochoa”, Madrid, Spain. His research group has a longstanding interest in the molecular and cellular mechanisms of synaptic plasticity, and their contribution to cognitive processes such as learning and memory. Using electrophysiological, imaging and molecular techniques, José Esteban has made important contributions to understand how the membrane trafficking machinery of the neuron controls synaptic function by shuttling neurotransmitter receptors in and out of the synaptic membrane. He is also particularly interested in how these processes are altered in human pathologies associated to cognitive disorders.
Selected references:
Arendt, K. L., Benoist, M., Lario, A., Draffin, J. E., Munoz, M. and Esteban, J. A. (2014) PTEN counteracts PIP3 upregulation in spines during NMDA-receptor-dependent long-term depression. J Cell Sci, 127, 5253-5260.
Benoist, M., Palenzuela, R., Rozas, C., Rojas, P., Tortosa, E., Morales, B., Gonzalez-Billault, C., Avila, J. and Esteban, J. A. (2013) MAP1B-dependent Rac activation is required for AMPA receptor endocytosis during long-term depression. EMBO J, 32, 2287-2299.
Brachet, A., Norwood, S., Brouwers, J. F., Palomer, E., Helms, J. B., Dotti, C. G. and Esteban, J. A. (2015) LTP-triggered cholesterol redistribution activates Cdc42 and drives AMPA receptor synaptic delivery. J Cell Biol, 208, 791-806.

 
Dr. Yasunory Hayashi is Team Leader at the Brain Science Institute, RIKEN, Japan. His laboratory studies the molecular mechanisms of synaptic and structural plasticity, and is dedicated to identifying the signal transduction machinery leading to the structural modification of dendritic spine.
Selected references:
Hosokawa, T., Mitsushima, D., Kaneko, R., Hayashi, Y. (2015) Stoichiometry and phosphoisotypes of hippocampal AMPA-type glutamate receptor phosphorylation. Neuron, 85, 60-7.
Bosch, M., Castro, J., Saneyoshi, T., Matsuno, H., Sur, M., Hayashi, Y. (2014) Structural and molecular remodeling of dendritic spine substructures during long-term potentiation. Neuron, 82, 444-59.
Mower, A.F., Kwok, S., Yu, H., Majewska, A.K., Okamoto, K., Hayashi, Y., Sur, M. (2011) Experience-dependent regulation of CaMKII activity within single visual cortex synapses in vivo. Proc Natl Acad Sci U S A., 108, 21241-6.

 
Dr. Huibert Mansvelder is Professor and Head of the Research Department at the Faculty of Earth and Life Sciences (Integrative Neurophysiology), University of Amsterdam. His main interests are to unravel and understand functioning of neuronal circuitries in brain areas that are known to participate in specific behaviors. In particular, his research group focus mainly on the prefrontal cortex (PFC) and ventral tegmental area (VTA).
Selected references:
Poorthuis, R. B., Bloem, B., Verhoog, M. B. and Mansvelder, H. D. (2013) Layer-specific interference with cholinergic signaling in the prefrontal cortex by smoking concentrations of nicotine. J Neurosci, 33, 4843-4853.
Testa-Silva, G., Verhoog, M. B., Linaro, D., de Kock, C. P., Baayen, J. C., Meredith, R. M., De Zeeuw, C. I., Giugliano, M. and Mansvelder, H. D. (2014) High bandwidth synaptic communication and frequency tracking in human neocortex. PLoS Biol, 12, e1002007.
Verhoog, M. B., Goriounova, N. A., Obermayer, J., Stroeder, J., Hjorth, J. J., Testa-Silva, G., Baayen, J. C., de Kock, C. P., Meredith, R. M. and Mansvelder, H. D. (2013) Mechanisms underlying the rules for associative plasticity at adult human neocortical synapses. J Neurosci, 33, 17197-17208.

 
Dr. Emily Osterweill is a Chancellor’s Fellow at the Centre for Integrative Physiology, University of Edinburgh, UK. Emily did her PhD at Yale University, and her post-doc in the laboratory of Dr. Mark Bear at MIT. She is interested in understanding the contribution of local protein synthesis to synaptic plasticity and learning, and in investigating the role of mRNA translation in autism spectrum disorders and intellectual disability (ASD/ID).
Selected references:
Auerbach, B. D., Osterweil, E. K. and Bear, M. F. (2011) Mutations causing syndromic autism define an axis of synaptic pathophysiology. Nature, 480, 63-68.
Osterweil, E. K., Chuang, S. C., Chubykin, A. A., Sidorov, M., Bianchi, R., Wong, R. K. and Bear, M. F. (2013) Lovastatin corrects excess protein synthesis and prevents epileptogenesis in a mouse model of fragile X syndrome. Neuron, 77, 243-250.
Osterweil, E. K., Krueger, D. D., Reinhold, K. and Bear, M. F. (2010) Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome. J Neurosci, 30, 15616-15627.

 
Dr. Patricia Salinas is Professor of Cellular Neurobiology at the University College of London, UK. She has been studying how neuronal networks are generated during development and the mechanisms involved in the complex pattern of axon guidance, dendritic arborization and synapse formation in the vertebrate nervous system. In particular, the laboratory of Dr. Patricia Salinas is interested in understanding the role and the mechanisms of action of Wnt proteins in the terminal remodelling of axons during the initial stages of synaptic contact and in the mechanisms by which Wnts proteins stimulate synaptic assembly.
Selected references:
Ciani, L., Boyle, K. A., Dickins, E., Sahores, M., Anane, D., Lopes, D. M., Gibb, A. J. and Salinas, P. C. (2011) Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca2+/Calmodulin-dependent protein kinase II. Proc Natl Acad Sci U S A, 108, 10732-10737.
Galli, S., Lopes, D. M., Ammari, R., Kopra, J., Millar, S. E., Gibb, A. and Salinas, P. C. (2014) Deficient Wnt signalling triggers striatal synaptic degeneration and impaired motor behaviour in adult mice. Nat Commun, 5, 4992.
Purro, S. A., Dickins, E. M. and Salinas, P. C. (2012) The secreted Wnt antagonist Dickkopf-1 is required for amyloid beta-mediated synaptic loss. J Neurosci, 32, 3492-3498.

 
Dr. Ana M. Sebastião is Director of the Unit of Neuroscience, Institute of Molecular Medicine, University of Lisbon. Her interests include adenosine receptors and the role played by endogenous adenosine in the nervous system, namely upon the fine-tuning of neuronal activity at the tripartite synapse. She has been mostly interested in the way adenosine receptors interact with other neuromodulatory systems, including neuropeptides, cannabinoids and neurotrophic factors.
Selected references:
Batalha, V. L., Pego, J. M., Fontinha, B. M., Costenla, A. R., Valadas, J. S., Baqi, Y., Radjainia, H., Muller, C. E., Sebastiao, A. M. and Lopes, L. V. (2013) Adenosine A2A receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation. Mol Psychiatry, 18, 320-331.
Diogenes, M. J., Neves-Tome, R., Fucile, S., Martinello, K., Scianni, M., Theofilas, P., Lopatar, J., Ribeiro, J. A., Maggi, L., Frenguelli, B. G., Limatola, C., Boison, D. and Sebastiao, A. M. (2014) Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase. Cereb Cortex, 24, 67-80.
Rombo, D. M., Dias, R. B., Duarte, S. T., Ribeiro, J. A., Lamsa, K. P. and Sebastiao, A. M. (2014) Adenosine A1 Receptor Suppresses Tonic GABAA Receptor Currents in Hippocampal Pyramidal Cells and in a Defined Subpopulation of Interneurons. Cereb Cortex. (in press).

 
Dr. Inna Slutsky is a Senior Lecturer at the Department of Physiology and Pharmacology and the Sagol School of Neuroscience at Tel Aviv University. Her research is focused on understanding the basic mechanisms that maintain synaptic plasticity and memory function and initiate memory dysfunction in Alzheimer’s disease.
Selected references:
Dolev, I., Fogel, H., Milshtein, H., Berdichevsky, Y., Lipstein, N., Brose, N., Gazit, N. and Slutsky, I. (2013) Spike bursts increase amyloid-beta 40/42 ratio by inducing a presenilin-1 conformational change. Nat Neurosci, 16, 587-595.
Fogel, H., Frere, S., Segev, O., Bharill, S., Shapira, I., Gazit, N., O'Malley, T., Slomowitz, E., Berdichevsky, Y., Walsh, D. M., Isacoff, E. Y., Hirsch, J. A. and Slutsky, I. (2014) APP homodimers transduce an amyloid-beta-mediated increase in release probability at excitatory synapses. Cell Rep, 7, 1560-1576.
Vertkin, I., Styr, B., Slomowitz, E., Ofir, N., Shapira, I., Berner, D., Fedorova, T., Laviv, T., Barak-Broner, N., Greitzer-Antes, D., Gassmann, M., Bettler, B., Lotan, I. and Slutsky, I. (2015) GABAB receptor deficiency causes failure of neuronal homeostasis in hippocampal networks. Proc Natl Acad Sci U S A, 112, E3291-3299.

 
Dr. Jakob Sørensen is currently Professor and Deputy Head of the Institute for Neuroscience and Pharmacology, University of Copenhagen. His research focuses on the molecular mechanisms of neurotransmitter release by way of vesicular exocytosis in the chemical synapse and in neurosecretory cells, from vesicular biogenesis to formation of the fusion pore.
Selected references:
Pinheiro, P. S., Jansen, A. M., de Wit, H., Tawfik, B., Madsen, K. L., Verhage, M., Gether, U. and Sorensen, J. B. (2014) The BAR domain protein PICK1 controls vesicle number and size in adrenal chromaffin cells. J Neurosci, 34, 10688-10700.
Walter, A. M., Kurps, J., de Wit, H., Schoning, S., Toft-Bertelsen, T. L., Lauks, J., Ziomkiewicz, I., Weiss, A. N., Schulz, A., Fischer von Mollard, G., Verhage, M. and Sorensen, J. B. (2014) The SNARE protein vti1a functions in dense-core vesicle biogenesis. EMBO J, 33, 1681-1697.
Wierda, K. D. and Sorensen, J. B. (2014) Innervation by a GABAergic neuron depresses spontaneous release in glutamatergic neurons and unveils the clamping phenotype of synaptotagmin-1. J Neurosci, 34, 2100-2110.

 
Dr. Ofer Yizhar is a senior scientist at the Department of Neurobiology at the Weizmann Institute of Science in Israel. His research focuses on the role of the prefrontal cortex in learning and motivated behavior, and on the development and refinement of optogenetic technologies for manipulating neural circuits.
Selected references:
Liang, L., Li, Y., Potter, C. J., Yizhar, O., Deisseroth, K., Tsien, R. W. and Luo, L. (2013) GABAergic projection neurons route selective olfactory inputs to specific higher-order neurons. Neuron, 79, 917-931.
Yamamoto, K., Tanei, Z., Hashimoto, T., Wakabayashi, T., Okuno, H., Naka, Y., Yizhar, O., Fenno, L. E., Fukayama, M., Bito, H., Cirrito, J. R., Holtzman, D. M., Deisseroth, K. and Iwatsubo, T. (2015) Chronic optogenetic activation augments abeta pathology in a mouse model of Alzheimer disease. Cell Rep, 11, 859-865.
Yizhar, O., Fenno, L. E., Davidson, T. J., Mogri, M. and Deisseroth, K. (2011) Optogenetics in neural systems. Neuron, 71, 9-34.

 
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