Endogenous circadian rhythms govern behavior and physiology, while circadian disruption is an environmental factor that impacts cognition by altering the circadian clock at a molecular level.
We modeled the effects of 2 sources of circadian disruption -activity occurring during typical rest periods and untimely light exposure – to evaluate the effects of circadian disruption on behavior and underlying neurochemistry. Firstly, adult Long-Evans rats of both sexes were maintained on a 12 h:12 h light:dark cycle and tested using a 5-choice serial reaction time task (5-CSRTT) under 3 conditions: 4 h into the dark phase with no exposure to ambient light during testing (control), 4 h into the dark phase with exposure to ambient light during testing, and 4 h into the light phase. Both models resulted in impulsive behavior and reduced attention compared to control.
We established that changes in the diurnal expression pattern occur in the clock gene Period 2 (Per2) in the light phase-tested model. Choline acetyltransferase (Chat) and Dopamine receptor1 (Drd1) showed rhythmic expression with peak expression during the dark phase regardless of light-testing condition.
Next, we performed drug challenges in a new rat cohort to examine the interaction between the cholinergic and dopaminergic neurotransmitter systems in regulating the behavioral changes caused by circadian disruption.
Human Cerberus (CER) ELISA Kit |
DLR-CER-Hu-48T |
DL Develop |
48T |
EUR 517 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Human Cerberus (CER) in samples from serum, plasma, tissue homogenates or other biological fluids. |
Human Cerberus (CER) ELISA Kit |
DLR-CER-Hu-96T |
DL Develop |
96T |
EUR 673 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Human Cerberus (CER) in samples from serum, plasma, tissue homogenates or other biological fluids. |
Mouse Cerberus (CER) ELISA Kit |
DLR-CER-Mu-48T |
DL Develop |
48T |
EUR 527 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Cerberus (CER) in samples from serum, plasma or other biological fluids. |
Mouse Cerberus (CER) ELISA Kit |
DLR-CER-Mu-96T |
DL Develop |
96T |
EUR 688 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Cerberus (CER) in samples from serum, plasma or other biological fluids. |
Human Cerberus (CER) ELISA Kit |
RDR-CER-Hu-48Tests |
Reddot Biotech |
48 Tests |
EUR 544 |
Human Cerberus (CER) ELISA Kit |
RDR-CER-Hu-96Tests |
Reddot Biotech |
96 Tests |
EUR 756 |
Mouse Cerberus (CER) ELISA Kit |
RDR-CER-Mu-48Tests |
Reddot Biotech |
48 Tests |
EUR 557 |
Mouse Cerberus (CER) ELISA Kit |
RDR-CER-Mu-96Tests |
Reddot Biotech |
96 Tests |
EUR 774 |
Cerberus (CER) Antibody |
20-abx175778 |
Abbexa |
|
|
|
Cerberus (CER) Antibody |
20-abx175779 |
Abbexa |
|
|
|
Cerberus (CER) Antibody |
20-abx175780 |
Abbexa |
|
|
|
Cerberus (CER) Antibody |
20-abx171669 |
Abbexa |
|
|
|
Sheep CER ELISA Kit |
ESC0097 |
Abclonal |
96Tests |
EUR 521 |
Mouse CER ELISA Kit |
EMC0097 |
Abclonal |
96Tests |
EUR 521 |
Anserini CER ELISA Kit |
EAC0097 |
Abclonal |
96Tests |
EUR 521 |
Rabbit CER ELISA Kit |
ERTC0097 |
Abclonal |
96Tests |
EUR 521 |
Monkey CER ELISA Kit |
EMKC0097 |
Abclonal |
96Tests |
EUR 521 |
Porcine CER ELISA Kit |
EPC0097 |
Abclonal |
96Tests |
EUR 521 |
Rat CER ELISA Kit |
ERC0097 |
Abclonal |
96Tests |
EUR 521 |
Human CER ELISA Kit |
EHC0097 |
Abclonal |
96Tests |
EUR 521 |
Canine CER ELISA Kit |
ECC0097 |
Abclonal |
96Tests |
EUR 521 |
Chicken CER ELISA Kit |
ECKC0097 |
Abclonal |
96Tests |
EUR 521 |
Goat CER ELISA Kit |
EGTC0097 |
Abclonal |
96Tests |
EUR 521 |
Bovine CER ELISA Kit |
EBC0097 |
Abclonal |
96Tests |
EUR 521 |
Human Cerebellin (CER) Antibody |
33279-05111 |
AssayPro |
150 ug |
EUR 261 |
Human Cerberus (CER) Protein |
20-abx652843 |
Abbexa |
-
EUR 578.00
-
EUR 258.00
-
EUR 1720.00
-
EUR 690.00
-
EUR 425.00
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Mouse Cerberus (CER) Protein |
20-abx652844 |
Abbexa |
-
EUR 578.00
-
EUR 258.00
-
EUR 1720.00
-
EUR 690.00
-
EUR 425.00
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Mouse Cerberus (CER) Protein |
20-abx652845 |
Abbexa |
-
EUR 578.00
-
EUR 258.00
-
EUR 1720.00
-
EUR 690.00
-
EUR 425.00
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Human Cerberus (CER)CLIA Kit |
SCC125Hu-10x96wellstestplate |
Cloud-Clone |
10x96-wells test plate |
EUR 5647.8 |
|
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Cerberus (CER) in serum, plasma and other biological fluids. |
Human Cerberus (CER)CLIA Kit |
SCC125Hu-1x48wellstestplate |
Cloud-Clone |
1x48-wells test plate |
EUR 552.76 |
|
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Cerberus (CER) in serum, plasma and other biological fluids. |
Human Cerberus (CER)CLIA Kit |
SCC125Hu-1x96wellstestplate |
Cloud-Clone |
1x96-wells test plate |
EUR 746.8 |
|
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Cerberus (CER) in serum, plasma and other biological fluids. |
Human Cerberus (CER)CLIA Kit |
SCC125Hu-5x96wellstestplate |
Cloud-Clone |
5x96-wells test plate |
EUR 3060.6 |
|
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Cerberus (CER) in serum, plasma and other biological fluids. |
Human Cerberus (CER) CLIA Kit |
4-SCC125Hu |
Cloud-Clone |
-
EUR 5698.00
-
EUR 3061.00
-
EUR 747.00
|
- 10 plates of 96 wells
- 5 plates of 96 wells
- 1 plate of 96 wells
|
|
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Human Cerberus (CER)Serum, plasma and other biological fluids |
Mouse Cerberus (CER)CLIA Kit |
SCC125Mu-10x96wellstestplate |
Cloud-Clone |
10x96-wells test plate |
EUR 5804.88 |
|
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Cerberus (CER) in serum, plasma and other biological fluids. |
Mouse Cerberus (CER)CLIA Kit |
SCC125Mu-1x48wellstestplate |
Cloud-Clone |
1x48-wells test plate |
EUR 565.7 |
|
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Cerberus (CER) in serum, plasma and other biological fluids. |
Mouse Cerberus (CER)CLIA Kit |
SCC125Mu-1x96wellstestplate |
Cloud-Clone |
1x96-wells test plate |
EUR 765.28 |
|
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Cerberus (CER) in serum, plasma and other biological fluids. |
Mouse Cerberus (CER)CLIA Kit |
SCC125Mu-5x96wellstestplate |
Cloud-Clone |
5x96-wells test plate |
EUR 3143.76 |
|
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Cerberus (CER) in serum, plasma and other biological fluids. |
Mouse Cerberus (CER) CLIA Kit |
4-SCC125Mu |
Cloud-Clone |
-
EUR 5855.00
-
EUR 3144.00
-
EUR 766.00
|
- 10 plates of 96 wells
- 5 plates of 96 wells
- 1 plate of 96 wells
|
|
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Mouse Cerberus (CER)Serum, plasma and other biological fluids |
Human Cerberus (CER) ELISA Kit |
SEC125Hu-10x96wellstestplate |
Cloud-Clone |
10x96-wells test plate |
EUR 4731.5 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Cerberus (CER) in serum, plasma, tissue homogenates and other biological fluids. |
Human Cerberus (CER) ELISA Kit |
SEC125Hu-1x48wellstestplate |
Cloud-Clone |
1x48-wells test plate |
EUR 477.3 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Cerberus (CER) in serum, plasma, tissue homogenates and other biological fluids. |
Human Cerberus (CER) ELISA Kit |
SEC125Hu-1x96wellstestplate |
Cloud-Clone |
1x96-wells test plate |
EUR 639 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Cerberus (CER) in serum, plasma, tissue homogenates and other biological fluids. |
Human Cerberus (CER) ELISA Kit |
SEC125Hu-5x96wellstestplate |
Cloud-Clone |
5x96-wells test plate |
EUR 2575.5 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Cerberus (CER) in serum, plasma, tissue homogenates and other biological fluids. |
Human Cerberus (CER) ELISA Kit |
4-SEC125Hu |
Cloud-Clone |
-
EUR 4782.00
-
EUR 2526.00
-
EUR 640.00
|
- 10 plates of 96 wells
- 5 plates of 96 wells
- 1 plate of 96 wells
|
|
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Cerberus (CER) in samples from Serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. |
Mouse Cerberus (CER) ELISA Kit |
SEC125Mu-10x96wellstestplate |
Cloud-Clone |
10x96-wells test plate |
EUR 4862.4 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Cerberus (CER) in serum, plasma and other biological fluids. |
Mouse Cerberus (CER) ELISA Kit |
SEC125Mu-1x48wellstestplate |
Cloud-Clone |
1x48-wells test plate |
EUR 488.08 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Cerberus (CER) in serum, plasma and other biological fluids. |
Mouse Cerberus (CER) ELISA Kit |
SEC125Mu-1x96wellstestplate |
Cloud-Clone |
1x96-wells test plate |
EUR 654.4 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Cerberus (CER) in serum, plasma and other biological fluids. |
Mouse Cerberus (CER) ELISA Kit |
SEC125Mu-5x96wellstestplate |
Cloud-Clone |
5x96-wells test plate |
EUR 2644.8 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Cerberus (CER) in serum, plasma and other biological fluids. |
Mouse Cerberus (CER) ELISA Kit |
4-SEC125Mu |
Cloud-Clone |
-
EUR 4913.00
-
EUR 2595.00
-
EUR 655.00
|
- 10 plates of 96 wells
- 5 plates of 96 wells
- 1 plate of 96 wells
|
|
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Cerberus (CER) in samples from Serum, plasma and other biological fluids. with no significant corss-reactivity with analogues from other species. |
Anserini CP/CER ELISA Kit |
EAC0813 |
Abclonal |
96Tests |
EUR 521 |
Rat CP/CER ELISA Kit |
ERC0813 |
Abclonal |
96Tests |
EUR 521 |
Rabbit CP/CER ELISA Kit |
ERTC0813 |
Abclonal |
96Tests |
EUR 521 |
Mouse CP/CER ELISA Kit |
EMC0813 |
Abclonal |
96Tests |
EUR 521 |
Porcine CP/CER ELISA Kit |
EPC0813 |
Abclonal |
96Tests |
EUR 521 |
Human CP/CER ELISA Kit |
EHC0813 |
Abclonal |
96Tests |
EUR 521 |
Canine CP/CER ELISA Kit |
ECC0813 |
Abclonal |
96Tests |
EUR 521 |
Guinea Pig CER ELISA Kit |
EGC0097 |
Abclonal |
96Tests |
EUR 521 |
Goat CP/CER ELISA Kit |
EGTC0813 |
Abclonal |
96Tests |
EUR 521 |
Bovine CP/CER ELISA Kit |
EBC0813 |
Abclonal |
96Tests |
EUR 521 |
Human Cerberus (CER)ELISA Kit |
201-12-2888 |
SunredBio |
96 tests |
EUR 440 |
|
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
Human Cerberus (CER) CLIA Kit |
20-abx190288 |
Abbexa |
-
EUR 7911.00
-
EUR 4215.00
-
EUR 973.00
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
Mouse Cerberus (CER) CLIA Kit |
20-abx190562 |
Abbexa |
-
EUR 7973.00
-
EUR 4246.00
-
EUR 981.00
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
Human Cerberus (CER) ELISA Kit |
20-abx151035 |
Abbexa |
-
EUR 7378.00
-
EUR 3933.00
-
EUR 911.00
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
Mouse Cerberus (CER) ELISA Kit |
20-abx153809 |
Abbexa |
-
EUR 7378.00
-
EUR 3933.00
-
EUR 911.00
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
CER ELISA Kit (Human) (OKCD04478) |
OKCD04478 |
Aviva Systems Biology |
96 Wells |
EUR 831 |
Description: Description of target: This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 13.3 pg/mL |
CER ELISA Kit (Mouse) (OKCD04479) |
OKCD04479 |
Aviva Systems Biology |
96 Wells |
EUR 857 |
Description: Description of target: ;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 11.7 pg/mL |
Human Ceruloplasmin, CP/CER ELISA Kit |
CSB-E08383h-24T |
Cusabio |
1 plate of 24 wells |
EUR 165 |
|
Description: Quantitativesandwich ELISA kit for measuring Human Ceruloplasmin, CP/CER in samples from serum, plasma, cell culture supernates, urine, saliva. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Human Ceruloplasmin, CP/CER ELISA Kit |
1-CSB-E08383h |
Cusabio |
-
EUR 703.00
-
EUR 4843.00
-
EUR 2570.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Human Ceruloplasmin, CP/CER in samples from serum, plasma, cell culture supernates, urine, saliva. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Mouse Ceruloplasmin, CP/CER ELISA Kit |
CSB-E07023m-24T |
Cusabio |
1 plate of 24 wells |
EUR 165 |
|
Description: Quantitativecompetitive ELISA kit for measuring Mouse Ceruloplasmin, CP/CER in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Mouse Ceruloplasmin, CP/CER ELISA Kit |
1-CSB-E07023m |
Cusabio |
-
EUR 946.00
-
EUR 5782.00
-
EUR 3060.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativecompetitive ELISA kit for measuring Mouse Ceruloplasmin, CP/CER in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
ELISA kit for Mouse CER (Cerberus) |
ELK6708 |
ELK Biotech |
1 plate of 96 wells |
EUR 432 |
|
Description: A sandwich ELISA kit for detection of Cerberus from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
Mouse Ceruloplasmin(CP/CER)ELISA Kit |
GA-E0264MS-48T |
GenAsia Biotech |
48T |
EUR 336 |
Mouse Ceruloplasmin(CP/CER)ELISA Kit |
GA-E0264MS-96T |
GenAsia Biotech |
96T |
EUR 534 |
Human Ceruloplasmin(CP/CER)ELISA Kit |
GA-E1246HM-48T |
GenAsia Biotech |
48T |
EUR 289 |
Human Ceruloplasmin(CP/CER)ELISA Kit |
GA-E1246HM-96T |
GenAsia Biotech |
96T |
EUR 466 |
ELISA kit for Human CER (Cerberus) |
ELK3677 |
ELK Biotech |
1 plate of 96 wells |
EUR 432 |
|
Description: A sandwich ELISA kit for detection of Cerberus from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
Guinea Pig CP/CER ELISA Kit |
EGC0813 |
Abclonal |
96Tests |
EUR 521 |
Human Cerebellin (CER) Antibody (Biotin Conjugate) |
33279-05121 |
AssayPro |
150 ug |
EUR 369 |
Human Ceruloplasmin,CP/CER ELISA Kit |
201-12-1230 |
SunredBio |
96 tests |
EUR 440 |
|
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
Mouse Ceruloplasmin,CP/CER ELISA Kit |
CN-02832M1 |
ChemNorm |
96T |
EUR 441 |
Mouse Ceruloplasmin,CP/CER ELISA Kit |
CN-02832M2 |
ChemNorm |
48T |
EUR 291 |
Human Ceruloplasmin,CP/CER ELISA Kit |
CN-04411H1 |
ChemNorm |
96T |
EUR 454 |
Human Ceruloplasmin,CP/CER ELISA Kit |
CN-04411H2 |
ChemNorm |
48T |
EUR 303 |
Rat Ceruloplasmin CP/CER ELISA kit |
E02C0806-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A Sandwich ELISA for quantitative measurement of Rat Ceruloplasmin CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Ceruloplasmin CP/CER ELISA kit |
E02C0806-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A Sandwich ELISA for quantitative measurement of Rat Ceruloplasmin CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Ceruloplasmin,CP/CER ELISA kit |
E02C1988-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Rat Ceruloplasmin,CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Ceruloplasmin,CP/CER ELISA kit |
E02C1988-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Rat Ceruloplasmin,CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Ceruloplasmin,CP/CER ELISA kit |
E02C1988-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Rat Ceruloplasmin,CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Ceruloplasmin CP/CER ELISA kit |
E02C0806-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A Sandwich ELISA for quantitative measurement of Rat Ceruloplasmin CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Ceruloplasmin,CP/CER ELISA kit |
E01C1988-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Human Ceruloplasmin,CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Ceruloplasmin,CP/CER ELISA kit |
E01C1988-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Human Ceruloplasmin,CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Ceruloplasmin,CP/CER ELISA kit |
E01C1988-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Human Ceruloplasmin,CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Ceruloplasmin,CP/CER ELISA kit |
E04C1988-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Rabbit Ceruloplasmin,CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Ceruloplasmin,CP/CER ELISA kit |
E04C1988-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Rabbit Ceruloplasmin,CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
We administered the cholinergic agonist nicotine and either the dopamine receptor 1 (DR1) antagonist SCH23390 or the DR2 antagonist eticlopride under the 3 circadian conditions to identify differential drug responses between treatment groups. Rats in both models demonstrated increased sensitivity to nicotine as compared to control, while SCH23390 and eticlopride ameliorated the effect of nicotine on 5-CSRTT performance in both models. Our study is the first to identify detrimental effects of both models of circadian disruption on impulsive behavior, and that the effects of circadian disruption are mediated by an interaction between cholinergic and dopaminergic systems.