Pharmacological challenges examining the underlying mechanism of altered response inhibition and attention due to circadian disruption in adult Long-Evans rats.

Endogenous circadian rhythms govern behavior and physiology, while circadian disruption is an environmental factor that impacts cognition by altering the circadian clock at a molecular level.

We modeled the effects of 2 sources of circadian disruption -activity occurring during typical rest periods and untimely light exposure – to evaluate the effects of circadian disruption on behavior and underlying neurochemistry. Firstly, adult Long-Evans rats of both sexes were maintained on a 12 h:12 h light:dark cycle and tested using a 5-choice serial reaction time task (5-CSRTT) under 3 conditions: 4 h into the dark phase with no exposure to ambient light during testing (control), 4 h into the dark phase with exposure to ambient light during testing, and 4 h into the light phase. Both models resulted in impulsive behavior and reduced attention compared to control.

We established that changes in the diurnal expression pattern occur in the clock gene Period 2 (Per2) in the light phase-tested model. Choline acetyltransferase (Chat) and Dopamine receptor1 (Drd1) showed rhythmic expression with peak expression during the dark phase regardless of light-testing condition.

Next, we performed drug challenges in a new rat cohort to examine the interaction between the cholinergic and dopaminergic neurotransmitter systems in regulating the behavioral changes caused by circadian disruption.

Human Cerberus (CER) ELISA Kit

DLR-CER-Hu-48T 48T
EUR 517
Description: A sandwich quantitative ELISA assay kit for detection of Human Cerberus (CER) in samples from serum, plasma, tissue homogenates or other biological fluids.

Human Cerberus (CER) ELISA Kit

DLR-CER-Hu-96T 96T
EUR 673
Description: A sandwich quantitative ELISA assay kit for detection of Human Cerberus (CER) in samples from serum, plasma, tissue homogenates or other biological fluids.

Mouse Cerberus (CER) ELISA Kit

DLR-CER-Mu-48T 48T
EUR 527
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Cerberus (CER) in samples from serum, plasma or other biological fluids.

Mouse Cerberus (CER) ELISA Kit

DLR-CER-Mu-96T 96T
EUR 688
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Cerberus (CER) in samples from serum, plasma or other biological fluids.

Human Cerberus (CER) ELISA Kit

RDR-CER-Hu-48Tests 48 Tests
EUR 544

Human Cerberus (CER) ELISA Kit

RDR-CER-Hu-96Tests 96 Tests
EUR 756

Mouse Cerberus (CER) ELISA Kit

RDR-CER-Mu-48Tests 48 Tests
EUR 557

Mouse Cerberus (CER) ELISA Kit

RDR-CER-Mu-96Tests 96 Tests
EUR 774

Cerberus (CER) Antibody

20-abx175778
  • EUR 1205.00
  • EUR 578.00
  • 1 mg
  • 200 ug

Cerberus (CER) Antibody

20-abx175779
  • EUR 1233.00
  • EUR 592.00
  • 1 mg
  • 200 ug

Cerberus (CER) Antibody

20-abx175780
  • EUR 1233.00
  • EUR 592.00
  • 1 mg
  • 200 ug

Cerberus (CER) Antibody

20-abx171669
  • EUR 857.00
  • EUR 439.00
  • 1 mg
  • 200 ug

Sheep CER ELISA Kit

ESC0097 96Tests
EUR 521

Mouse CER ELISA Kit

EMC0097 96Tests
EUR 521

Anserini CER ELISA Kit

EAC0097 96Tests
EUR 521

Rabbit CER ELISA Kit

ERTC0097 96Tests
EUR 521

Monkey CER ELISA Kit

EMKC0097 96Tests
EUR 521

Porcine CER ELISA Kit

EPC0097 96Tests
EUR 521

Rat CER ELISA Kit

ERC0097 96Tests
EUR 521

Human CER ELISA Kit

EHC0097 96Tests
EUR 521

Canine CER ELISA Kit

ECC0097 96Tests
EUR 521

Chicken CER ELISA Kit

ECKC0097 96Tests
EUR 521

Goat CER ELISA Kit

EGTC0097 96Tests
EUR 521

Bovine CER ELISA Kit

EBC0097 96Tests
EUR 521

Human Cerebellin (CER) Antibody

33279-05111 150 ug
EUR 261

Human Cerberus (CER) Protein

20-abx652843
  • EUR 578.00
  • EUR 258.00
  • EUR 1720.00
  • EUR 690.00
  • EUR 425.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Cerberus (CER) Protein

20-abx652844
  • EUR 578.00
  • EUR 258.00
  • EUR 1720.00
  • EUR 690.00
  • EUR 425.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Cerberus (CER) Protein

20-abx652845
  • EUR 578.00
  • EUR 258.00
  • EUR 1720.00
  • EUR 690.00
  • EUR 425.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Cerberus (CER)CLIA Kit

SCC125Hu-10x96wellstestplate 10x96-wells test plate
EUR 5647.8
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Cerberus (CER) in serum, plasma and other biological fluids.

Human Cerberus (CER)CLIA Kit

SCC125Hu-1x48wellstestplate 1x48-wells test plate
EUR 552.76
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Cerberus (CER) in serum, plasma and other biological fluids.

Human Cerberus (CER)CLIA Kit

SCC125Hu-1x96wellstestplate 1x96-wells test plate
EUR 746.8
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Cerberus (CER) in serum, plasma and other biological fluids.

Human Cerberus (CER)CLIA Kit

SCC125Hu-5x96wellstestplate 5x96-wells test plate
EUR 3060.6
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Cerberus (CER) in serum, plasma and other biological fluids.

Human Cerberus (CER) CLIA Kit

4-SCC125Hu
  • EUR 5698.00
  • EUR 3061.00
  • EUR 747.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Human Cerberus (CER)Serum, plasma and other biological fluids

Mouse Cerberus (CER)CLIA Kit

SCC125Mu-10x96wellstestplate 10x96-wells test plate
EUR 5804.88
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Cerberus (CER) in serum, plasma and other biological fluids.

Mouse Cerberus (CER)CLIA Kit

SCC125Mu-1x48wellstestplate 1x48-wells test plate
EUR 565.7
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Cerberus (CER) in serum, plasma and other biological fluids.

Mouse Cerberus (CER)CLIA Kit

SCC125Mu-1x96wellstestplate 1x96-wells test plate
EUR 765.28
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Cerberus (CER) in serum, plasma and other biological fluids.

Mouse Cerberus (CER)CLIA Kit

SCC125Mu-5x96wellstestplate 5x96-wells test plate
EUR 3143.76
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Cerberus (CER) in serum, plasma and other biological fluids.

Mouse Cerberus (CER) CLIA Kit

4-SCC125Mu
  • EUR 5855.00
  • EUR 3144.00
  • EUR 766.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Mouse Cerberus (CER)Serum, plasma and other biological fluids

Human Cerberus (CER) ELISA Kit

SEC125Hu-10x96wellstestplate 10x96-wells test plate
EUR 4731.5
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Cerberus (CER) in serum, plasma, tissue homogenates and other biological fluids.

Human Cerberus (CER) ELISA Kit

SEC125Hu-1x48wellstestplate 1x48-wells test plate
EUR 477.3
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Cerberus (CER) in serum, plasma, tissue homogenates and other biological fluids.

Human Cerberus (CER) ELISA Kit

SEC125Hu-1x96wellstestplate 1x96-wells test plate
EUR 639
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Cerberus (CER) in serum, plasma, tissue homogenates and other biological fluids.

Human Cerberus (CER) ELISA Kit

SEC125Hu-5x96wellstestplate 5x96-wells test plate
EUR 2575.5
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Cerberus (CER) in serum, plasma, tissue homogenates and other biological fluids.

Human Cerberus (CER) ELISA Kit

4-SEC125Hu
  • EUR 4782.00
  • EUR 2526.00
  • EUR 640.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Cerberus (CER) in samples from Serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species.

Mouse Cerberus (CER) ELISA Kit

SEC125Mu-10x96wellstestplate 10x96-wells test plate
EUR 4862.4
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Cerberus (CER) in serum, plasma and other biological fluids.

Mouse Cerberus (CER) ELISA Kit

SEC125Mu-1x48wellstestplate 1x48-wells test plate
EUR 488.08
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Cerberus (CER) in serum, plasma and other biological fluids.

Mouse Cerberus (CER) ELISA Kit

SEC125Mu-1x96wellstestplate 1x96-wells test plate
EUR 654.4
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Cerberus (CER) in serum, plasma and other biological fluids.

Mouse Cerberus (CER) ELISA Kit

SEC125Mu-5x96wellstestplate 5x96-wells test plate
EUR 2644.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Cerberus (CER) in serum, plasma and other biological fluids.

Mouse Cerberus (CER) ELISA Kit

4-SEC125Mu
  • EUR 4913.00
  • EUR 2595.00
  • EUR 655.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Cerberus (CER) in samples from Serum, plasma and other biological fluids. with no significant corss-reactivity with analogues from other species.

Anserini CP/CER ELISA Kit

EAC0813 96Tests
EUR 521

Rat CP/CER ELISA Kit

ERC0813 96Tests
EUR 521

Rabbit CP/CER ELISA Kit

ERTC0813 96Tests
EUR 521

Mouse CP/CER ELISA Kit

EMC0813 96Tests
EUR 521

Porcine CP/CER ELISA Kit

EPC0813 96Tests
EUR 521

Human CP/CER ELISA Kit

EHC0813 96Tests
EUR 521

Canine CP/CER ELISA Kit

ECC0813 96Tests
EUR 521

Guinea Pig CER ELISA Kit

EGC0097 96Tests
EUR 521

Goat CP/CER ELISA Kit

EGTC0813 96Tests
EUR 521

Bovine CP/CER ELISA Kit

EBC0813 96Tests
EUR 521

Human Cerberus (CER)ELISA Kit

201-12-2888 96 tests
EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Cerberus (CER) CLIA Kit

20-abx190288
  • EUR 7911.00
  • EUR 4215.00
  • EUR 973.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Cerberus (CER) CLIA Kit

20-abx190562
  • EUR 7973.00
  • EUR 4246.00
  • EUR 981.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Cerberus (CER) ELISA Kit

20-abx151035
  • EUR 7378.00
  • EUR 3933.00
  • EUR 911.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Cerberus (CER) ELISA Kit

20-abx153809
  • EUR 7378.00
  • EUR 3933.00
  • EUR 911.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

CER ELISA Kit (Human) (OKCD04478)

OKCD04478 96 Wells
EUR 831
Description: Description of target: This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 13.3 pg/mL

CER ELISA Kit (Mouse) (OKCD04479)

OKCD04479 96 Wells
EUR 857
Description: Description of target: ;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 11.7 pg/mL

Human Cerberus(CER)ELISA Kit

QY-E05054 96T
EUR 413

Human Ceruloplasmin, CP/CER ELISA Kit

CSB-E08383h-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Human Ceruloplasmin, CP/CER in samples from serum, plasma, cell culture supernates, urine, saliva. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Ceruloplasmin, CP/CER ELISA Kit

1-CSB-E08383h
  • EUR 703.00
  • EUR 4843.00
  • EUR 2570.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Ceruloplasmin, CP/CER in samples from serum, plasma, cell culture supernates, urine, saliva. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Ceruloplasmin, CP/CER ELISA Kit

CSB-E07023m-24T 1 plate of 24 wells
EUR 165
Description: Quantitativecompetitive ELISA kit for measuring Mouse Ceruloplasmin, CP/CER in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Ceruloplasmin, CP/CER ELISA Kit

1-CSB-E07023m
  • EUR 946.00
  • EUR 5782.00
  • EUR 3060.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativecompetitive ELISA kit for measuring Mouse Ceruloplasmin, CP/CER in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

ELISA kit for Mouse CER (Cerberus)

ELK6708 1 plate of 96 wells
EUR 432
Description: A sandwich ELISA kit for detection of Cerberus from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Mouse Ceruloplasmin(CP/CER)ELISA Kit    

GA-E0264MS-48T 48T
EUR 336

Mouse Ceruloplasmin(CP/CER)ELISA Kit    

GA-E0264MS-96T 96T
EUR 534

Human Ceruloplasmin(CP/CER)ELISA Kit

GA-E1246HM-48T 48T
EUR 289

Human Ceruloplasmin(CP/CER)ELISA Kit

GA-E1246HM-96T 96T
EUR 466

ELISA kit for Human CER (Cerberus)

ELK3677 1 plate of 96 wells
EUR 432
Description: A sandwich ELISA kit for detection of Cerberus from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Guinea Pig CP/CER ELISA Kit

EGC0813 96Tests
EUR 521

Human Cerebellin (CER) Antibody (Biotin Conjugate)

33279-05121 150 ug
EUR 369

Human Ceruloplasmin,CP/CER ELISA Kit

201-12-1230 96 tests
EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Ceruloplasmin(CP/CER)ELISA Kit

QY-E01220 96T
EUR 361

Mouse Ceruloplasmin,CP/CER ELISA Kit

CN-02832M1 96T
EUR 441

Mouse Ceruloplasmin,CP/CER ELISA Kit

CN-02832M2 48T
EUR 291

Human Ceruloplasmin,CP/CER ELISA Kit

CN-04411H1 96T
EUR 454

Human Ceruloplasmin,CP/CER ELISA Kit

CN-04411H2 48T
EUR 303

Mouse Ceruloplasmin, CP/ CER ELISA Kit

ELA-E0909m 96 Tests
EUR 865

Rat Ceruloplasmin CP/CER ELISA kit

E02C0806-192T 192 tests
EUR 1270
Description: A Sandwich ELISA for quantitative measurement of Rat Ceruloplasmin CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Ceruloplasmin CP/CER ELISA kit

E02C0806-96 1 plate of 96 wells
EUR 685
Description: A Sandwich ELISA for quantitative measurement of Rat Ceruloplasmin CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Ceruloplasmin,CP/CER ELISA kit

E02C1988-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Rat Ceruloplasmin,CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Ceruloplasmin,CP/CER ELISA kit

E02C1988-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Rat Ceruloplasmin,CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Ceruloplasmin,CP/CER ELISA kit

E02C1988-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rat Ceruloplasmin,CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Ceruloplasmin CP/CER ELISA kit

E02C0806-48 1 plate of 48 wells
EUR 520
Description: A Sandwich ELISA for quantitative measurement of Rat Ceruloplasmin CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ceruloplasmin,CP/CER ELISA kit

E01C1988-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Human Ceruloplasmin,CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ceruloplasmin,CP/CER ELISA kit

E01C1988-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Human Ceruloplasmin,CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ceruloplasmin,CP/CER ELISA kit

E01C1988-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Human Ceruloplasmin,CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Ceruloplasmin,CP/CER ELISA kit

E04C1988-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Rabbit Ceruloplasmin,CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Ceruloplasmin,CP/CER ELISA kit

E04C1988-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Rabbit Ceruloplasmin,CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

We administered the cholinergic agonist nicotine and either the dopamine receptor 1 (DR1) antagonist SCH23390 or the DR2 antagonist eticlopride under the 3 circadian conditions to identify differential drug responses between treatment groups. Rats in both models demonstrated increased sensitivity to nicotine as compared to control, while SCH23390 and eticlopride ameliorated the effect of nicotine on 5-CSRTT performance in both models. Our study is the first to identify detrimental effects of both models of circadian disruption on impulsive behavior, and that the effects of circadian disruption are mediated by an interaction between cholinergic and dopaminergic systems.