Pharmacological challenges examining the underlying mechanism of altered response inhibition and attention due to circadian disruption in adult Long-Evans rats.

Endogenous circadian rhythms govern behavior and physiology, while circadian disruption is an environmental factor that impacts cognition by altering the circadian clock at a molecular level.

We modeled the effects of 2 sources of circadian disruption -activity occurring during typical rest periods and untimely light exposure – to evaluate the effects of circadian disruption on behavior and underlying neurochemistry. Firstly, adult Long-Evans rats of both sexes were maintained on a 12 h:12 h light:dark cycle and tested using a 5-choice serial reaction time task (5-CSRTT) under 3 conditions: 4 h into the dark phase with no exposure to ambient light during testing (control), 4 h into the dark phase with exposure to ambient light during testing, and 4 h into the light phase. Both models resulted in impulsive behavior and reduced attention compared to control.

We established that changes in the diurnal expression pattern occur in the clock gene Period 2 (Per2) in the light phase-tested model. Choline acetyltransferase (Chat) and Dopamine receptor1 (Drd1) showed rhythmic expression with peak expression during the dark phase regardless of light-testing condition.

Next, we performed drug challenges in a new rat cohort to examine the interaction between the cholinergic and dopaminergic neurotransmitter systems in regulating the behavioral changes caused by circadian disruption.

Human Cerberus (CER) ELISA Kit
DLR-CER-Hu-48T	DL Develop	48T	EUR 517
Description: A sandwich quantitative ELISA assay kit for detection of Human Cerberus (CER) in samples from serum, plasma, tissue homogenates or other biological fluids.

Human Cerberus (CER) ELISA Kit
DLR-CER-Hu-96T	DL Develop	96T	EUR 673
Description: A sandwich quantitative ELISA assay kit for detection of Human Cerberus (CER) in samples from serum, plasma, tissue homogenates or other biological fluids.

Mouse Cerberus (CER) ELISA Kit
DLR-CER-Mu-48T	DL Develop	48T	EUR 527
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Cerberus (CER) in samples from serum, plasma or other biological fluids.

Mouse Cerberus (CER) ELISA Kit
DLR-CER-Mu-96T	DL Develop	96T	EUR 688
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Cerberus (CER) in samples from serum, plasma or other biological fluids.

Human Cerberus (CER) ELISA Kit
RDR-CER-Hu-48Tests	Reddot Biotech	48 Tests	EUR 544

Human Cerberus (CER) ELISA Kit
RDR-CER-Hu-96Tests	Reddot Biotech	96 Tests	EUR 756

Mouse Cerberus (CER) ELISA Kit
RDR-CER-Mu-48Tests	Reddot Biotech	48 Tests	EUR 557

Mouse Cerberus (CER) ELISA Kit
RDR-CER-Mu-96Tests	Reddot Biotech	96 Tests	EUR 774

Cerberus (CER) Antibody
20-abx175778	Abbexa	EUR 1205.00 EUR 578.00	1 mg 200 ug

Cerberus (CER) Antibody
20-abx175779	Abbexa	EUR 1233.00 EUR 592.00	1 mg 200 ug

Cerberus (CER) Antibody
20-abx175780	Abbexa	EUR 1233.00 EUR 592.00	1 mg 200 ug

Cerberus (CER) Antibody
20-abx171669	Abbexa	EUR 857.00 EUR 439.00	1 mg 200 ug

Sheep CER ELISA Kit
ESC0097	Abclonal	96Tests	EUR 521

Mouse CER ELISA Kit
EMC0097	Abclonal	96Tests	EUR 521

Anserini CER ELISA Kit
EAC0097	Abclonal	96Tests	EUR 521

Rabbit CER ELISA Kit
ERTC0097	Abclonal	96Tests	EUR 521

Monkey CER ELISA Kit
EMKC0097	Abclonal	96Tests	EUR 521

Porcine CER ELISA Kit
EPC0097	Abclonal	96Tests	EUR 521

Rat CER ELISA Kit
ERC0097	Abclonal	96Tests	EUR 521

Human CER ELISA Kit
EHC0097	Abclonal	96Tests	EUR 521

Canine CER ELISA Kit
ECC0097	Abclonal	96Tests	EUR 521

Chicken CER ELISA Kit
ECKC0097	Abclonal	96Tests	EUR 521

Goat CER ELISA Kit
EGTC0097	Abclonal	96Tests	EUR 521

Bovine CER ELISA Kit
EBC0097	Abclonal	96Tests	EUR 521

Human Cerebellin (CER) Antibody
33279-05111	AssayPro	150 ug	EUR 261

Human Cerberus (CER) Protein
20-abx652843	Abbexa	EUR 578.00 EUR 258.00 EUR 1720.00 EUR 690.00 EUR 425.00	100 ug 10 ug 1 mg 200 ug 50 ug

Mouse Cerberus (CER) Protein
20-abx652844	Abbexa	EUR 578.00 EUR 258.00 EUR 1720.00 EUR 690.00 EUR 425.00	100 ug 10 ug 1 mg 200 ug 50 ug

Mouse Cerberus (CER) Protein
20-abx652845	Abbexa	EUR 578.00 EUR 258.00 EUR 1720.00 EUR 690.00 EUR 425.00	100 ug 10 ug 1 mg 200 ug 50 ug

Human Cerberus (CER)CLIA Kit
SCC125Hu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 5647.8
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Cerberus (CER) in serum, plasma and other biological fluids.

Human Cerberus (CER)CLIA Kit
SCC125Hu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 552.76
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Cerberus (CER) in serum, plasma and other biological fluids.

Human Cerberus (CER)CLIA Kit
SCC125Hu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 746.8
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Cerberus (CER) in serum, plasma and other biological fluids.

Human Cerberus (CER)CLIA Kit
SCC125Hu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 3060.6
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Cerberus (CER) in serum, plasma and other biological fluids.

Human Cerberus (CER) CLIA Kit
4-SCC125Hu	Cloud-Clone	EUR 5698.00 EUR 3061.00 EUR 747.00	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Human Cerberus (CER)Serum, plasma and other biological fluids

Mouse Cerberus (CER)CLIA Kit
SCC125Mu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 5804.88
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Cerberus (CER) in serum, plasma and other biological fluids.

Mouse Cerberus (CER)CLIA Kit
SCC125Mu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 565.7
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Cerberus (CER) in serum, plasma and other biological fluids.

Mouse Cerberus (CER)CLIA Kit
SCC125Mu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 765.28
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Cerberus (CER) in serum, plasma and other biological fluids.

Mouse Cerberus (CER)CLIA Kit
SCC125Mu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 3143.76
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Cerberus (CER) in serum, plasma and other biological fluids.

Mouse Cerberus (CER) CLIA Kit
4-SCC125Mu	Cloud-Clone	EUR 5855.00 EUR 3144.00 EUR 766.00	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Mouse Cerberus (CER)Serum, plasma and other biological fluids

Human Cerberus (CER) ELISA Kit
SEC125Hu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 4731.5
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Cerberus (CER) in serum, plasma, tissue homogenates and other biological fluids.

Human Cerberus (CER) ELISA Kit
SEC125Hu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 477.3
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Cerberus (CER) in serum, plasma, tissue homogenates and other biological fluids.

Human Cerberus (CER) ELISA Kit
SEC125Hu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 639
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Cerberus (CER) in serum, plasma, tissue homogenates and other biological fluids.

Human Cerberus (CER) ELISA Kit
SEC125Hu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 2575.5
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Cerberus (CER) in serum, plasma, tissue homogenates and other biological fluids.

Human Cerberus (CER) ELISA Kit
4-SEC125Hu	Cloud-Clone	EUR 4782.00 EUR 2526.00 EUR 640.00	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Cerberus (CER) in samples from Serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species.

Mouse Cerberus (CER) ELISA Kit
SEC125Mu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 4862.4
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Cerberus (CER) in serum, plasma and other biological fluids.

Mouse Cerberus (CER) ELISA Kit
SEC125Mu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 488.08
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Cerberus (CER) in serum, plasma and other biological fluids.

Mouse Cerberus (CER) ELISA Kit
SEC125Mu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 654.4
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Cerberus (CER) in serum, plasma and other biological fluids.

Mouse Cerberus (CER) ELISA Kit
SEC125Mu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 2644.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Cerberus (CER) in serum, plasma and other biological fluids.

Mouse Cerberus (CER) ELISA Kit
4-SEC125Mu	Cloud-Clone	EUR 4913.00 EUR 2595.00 EUR 655.00	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Cerberus (CER) in samples from Serum, plasma and other biological fluids. with no significant corss-reactivity with analogues from other species.

Anserini CP/CER ELISA Kit
EAC0813	Abclonal	96Tests	EUR 521

Rat CP/CER ELISA Kit
ERC0813	Abclonal	96Tests	EUR 521

Rabbit CP/CER ELISA Kit
ERTC0813	Abclonal	96Tests	EUR 521

Mouse CP/CER ELISA Kit
EMC0813	Abclonal	96Tests	EUR 521

Porcine CP/CER ELISA Kit
EPC0813	Abclonal	96Tests	EUR 521

Human CP/CER ELISA Kit
EHC0813	Abclonal	96Tests	EUR 521

Canine CP/CER ELISA Kit
ECC0813	Abclonal	96Tests	EUR 521

Guinea Pig CER ELISA Kit
EGC0097	Abclonal	96Tests	EUR 521

Goat CP/CER ELISA Kit
EGTC0813	Abclonal	96Tests	EUR 521

Bovine CP/CER ELISA Kit
EBC0813	Abclonal	96Tests	EUR 521

Human Cerberus (CER)ELISA Kit
201-12-2888	SunredBio	96 tests	EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Cerberus (CER) CLIA Kit
20-abx190288	Abbexa	EUR 7911.00 EUR 4215.00 EUR 973.00	10 × 96 tests 5 × 96 tests 96 tests

Mouse Cerberus (CER) CLIA Kit
20-abx190562	Abbexa	EUR 7973.00 EUR 4246.00 EUR 981.00	10 × 96 tests 5 × 96 tests 96 tests

Human Cerberus (CER) ELISA Kit
20-abx151035	Abbexa	EUR 7378.00 EUR 3933.00 EUR 911.00	10 × 96 tests 5 × 96 tests 96 tests

Mouse Cerberus (CER) ELISA Kit
20-abx153809	Abbexa	EUR 7378.00 EUR 3933.00 EUR 911.00	10 × 96 tests 5 × 96 tests 96 tests

CER ELISA Kit (Human) (OKCD04478)
OKCD04478	Aviva Systems Biology	96 Wells	EUR 831
Description: Description of target: This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 13.3 pg/mL

CER ELISA Kit (Mouse) (OKCD04479)
OKCD04479	Aviva Systems Biology	96 Wells	EUR 857
Description: Description of target: ;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 11.7 pg/mL

Human Cerberus(CER)ELISA Kit
QY-E05054	Qayee Biotechnology	96T	EUR 413

Human Ceruloplasmin, CP/CER ELISA Kit
CSB-E08383h-24T	Cusabio	1 plate of 24 wells	EUR 165
Description: Quantitativesandwich ELISA kit for measuring Human Ceruloplasmin, CP/CER in samples from serum, plasma, cell culture supernates, urine, saliva. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Ceruloplasmin, CP/CER ELISA Kit
1-CSB-E08383h	Cusabio	EUR 703.00 EUR 4843.00 EUR 2570.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Ceruloplasmin, CP/CER in samples from serum, plasma, cell culture supernates, urine, saliva. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Ceruloplasmin, CP/CER ELISA Kit
CSB-E07023m-24T	Cusabio	1 plate of 24 wells	EUR 165
Description: Quantitativecompetitive ELISA kit for measuring Mouse Ceruloplasmin, CP/CER in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Ceruloplasmin, CP/CER ELISA Kit
1-CSB-E07023m	Cusabio	EUR 946.00 EUR 5782.00 EUR 3060.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativecompetitive ELISA kit for measuring Mouse Ceruloplasmin, CP/CER in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

ELISA kit for Mouse CER (Cerberus)
ELK6708	ELK Biotech	1 plate of 96 wells	EUR 432
Description: A sandwich ELISA kit for detection of Cerberus from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Mouse Ceruloplasmin(CP/CER)ELISA Kit
GA-E0264MS-48T	GenAsia Biotech	48T	EUR 336

Mouse Ceruloplasmin(CP/CER)ELISA Kit
GA-E0264MS-96T	GenAsia Biotech	96T	EUR 534

Human Ceruloplasmin(CP/CER)ELISA Kit
GA-E1246HM-48T	GenAsia Biotech	48T	EUR 289

Human Ceruloplasmin(CP/CER)ELISA Kit
GA-E1246HM-96T	GenAsia Biotech	96T	EUR 466

ELISA kit for Human CER (Cerberus)
ELK3677	ELK Biotech	1 plate of 96 wells	EUR 432
Description: A sandwich ELISA kit for detection of Cerberus from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Guinea Pig CP/CER ELISA Kit
EGC0813	Abclonal	96Tests	EUR 521

Human Cerebellin (CER) Antibody (Biotin Conjugate)
33279-05121	AssayPro	150 ug	EUR 369

Human Ceruloplasmin,CP/CER ELISA Kit
201-12-1230	SunredBio	96 tests	EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Ceruloplasmin(CP/CER)ELISA Kit
QY-E01220	Qayee Biotechnology	96T	EUR 361

Mouse Ceruloplasmin,CP/CER ELISA Kit
CN-02832M1	ChemNorm	96T	EUR 441

Mouse Ceruloplasmin,CP/CER ELISA Kit
CN-02832M2	ChemNorm	48T	EUR 291

Human Ceruloplasmin,CP/CER ELISA Kit
CN-04411H1	ChemNorm	96T	EUR 454

Human Ceruloplasmin,CP/CER ELISA Kit
CN-04411H2	ChemNorm	48T	EUR 303

Mouse Ceruloplasmin, CP/ CER ELISA Kit
ELA-E0909m	Lifescience Market	96 Tests	EUR 865

Rat Ceruloplasmin CP/CER ELISA kit
E02C0806-192T	BlueGene	192 tests	EUR 1270
Description: A Sandwich ELISA for quantitative measurement of Rat Ceruloplasmin CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Ceruloplasmin CP/CER ELISA kit
E02C0806-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A Sandwich ELISA for quantitative measurement of Rat Ceruloplasmin CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Ceruloplasmin,CP/CER ELISA kit
E02C1988-192T	BlueGene	192 tests	EUR 1270
Description: A competitive ELISA for quantitative measurement of Rat Ceruloplasmin,CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Ceruloplasmin,CP/CER ELISA kit
E02C1988-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A competitive ELISA for quantitative measurement of Rat Ceruloplasmin,CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Ceruloplasmin,CP/CER ELISA kit
E02C1988-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Rat Ceruloplasmin,CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Ceruloplasmin CP/CER ELISA kit
E02C0806-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A Sandwich ELISA for quantitative measurement of Rat Ceruloplasmin CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ceruloplasmin,CP/CER ELISA kit
E01C1988-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Human Ceruloplasmin,CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ceruloplasmin,CP/CER ELISA kit
E01C1988-192T	BlueGene	192 tests	EUR 1270
Description: A competitive ELISA for quantitative measurement of Human Ceruloplasmin,CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ceruloplasmin,CP/CER ELISA kit
E01C1988-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A competitive ELISA for quantitative measurement of Human Ceruloplasmin,CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Ceruloplasmin,CP/CER ELISA kit
E04C1988-192T	BlueGene	192 tests	EUR 1270
Description: A competitive ELISA for quantitative measurement of Rabbit Ceruloplasmin,CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Ceruloplasmin,CP/CER ELISA kit
E04C1988-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A competitive ELISA for quantitative measurement of Rabbit Ceruloplasmin,CP/CER in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

We administered the cholinergic agonist nicotine and either the dopamine receptor 1 (DR1) antagonist SCH23390 or the DR2 antagonist eticlopride under the 3 circadian conditions to identify differential drug responses between treatment groups. Rats in both models demonstrated increased sensitivity to nicotine as compared to control, while SCH23390 and eticlopride ameliorated the effect of nicotine on 5-CSRTT performance in both models. Our study is the first to identify detrimental effects of both models of circadian disruption on impulsive behavior, and that the effects of circadian disruption are mediated by an interaction between cholinergic and dopaminergic systems.